Hospital del Mar Research Institute Hospital del Mar Research Institute

PuigLab - Research lines

  • Study of the neural substrates underlying serotonergic and dopaminergic modulation of neural network activity and inter-area communication and its impact on executive function.
  • Deepen our understanding on the effects of typical (1st generation) and atypical (2nd generation) antipsychotic drugs on executive function and elucidate the cellular mechanisms involved.
  • Study of the neural substrates underlying deficits in executive function of murine models of intellectual disability. Models currently used: Down syndrome (Ts65Dn mice with partial trisomy equivalent to human chromosome 21) and the subchronic phencyclidine (PCP) model of schizophrenia. We also investigate the neural substrates of cognitive enhancers, natural compounds and environmental stimulation in these animal models.
  • Photopharmacology: In vivo testing of novel drugs sensitive to light for treatment of psychiatric and neurological disorders (in collaboration with Pau Gorostiza at IBEC, Barcelona).
  • Graphene-based neural interfaces: In vivo testing of neural probes made of graphene for high fidelity recording of neural activity (in collaboration with Jose Antonio Garrido at ICN2, Barcelona).

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