IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

Translational research in colorectal neoplasia Montserrat Andreu

A clinical research group lead by Dr. Montserrat Andreu García that was founded in 1999 and that has been directed towards the study of different forms of hereditary and familiar colon cancer.

In 1999 we began our line of research with the cooperative project EPICOLON, a population-based, nation-wide epidemiological, prospective and multicentric study. The objective of the study was to broaden epidemiological and molecular knowledge of Lynch syndrome and other hereditary or familiar forms of colorectal cancer (CCR). More than 25 hospitals throughout all of Spain participated. From November 2000 to October 2001, almost 2,000 patients with CCR were registered in this project. A detailed individual and family history centred on neoplastic antecedents was collected from each of them, as well as samples of tumour and non-tumour tissue. Our group, along with the digestive oncology group at the Hospital Clínico in Barcelona, Hospital Germans Trias i Pujol in Badalona and Hospital General Universitario de Alicante, coordinated this study and carried out the various analyses. Fis (01/0104-01). Lead Researcher: Dr. Montserrat Andreu.

Begun in June 2006, the new project, EPICOLON II, is oriented towards continuing to study the molecular bases of the hereditary and familiar forms of CCR in depth. This project has been strengthened by the participation of the Spanish National Genotyping Centre (CeGen) in Santiago de Compostela, in addition to all the groups that participated in the previous project. It has been designed in the same manner, collecting the CCR cases admitted to 16 centres throughout Spain over the past 1.5 years (June 2006-December 2007). An individual and family history centred on neoplastic antecedents was collected from each of them, along with biological samples.

The objectives set forth can be summarised into 4 sub-projects: (FIS No. P1061384 ) Dr. Montserrat Andreu. Period of validity: 2006-2009.

  • Project 1.- "Hyperplastic polyposis syndrome in a colorectal cancer population. Identification of tumours that may progress through the serrated pathway." Coordination: Hospital del Mar. Barcelona. Lead Researcher: Dr. Xavier Bessa
  • Project 2.- "Genomic ligation in families with Lynch syndrome without involvement of the mutator pathway and in hereditary CRC forms with recessive inheritance without alterations in MYH. It will cordero." Coordinated by Dr. X. LLor, University of Illinois at Chicago. Section of Digestive Diseases and Nutrition
  • Project 3.- "Histopathological and Immunochemical characterisation of sub-groups of sporadic and hereditary colorectal carcinoma previously defined by genomic expression profiles." Coordinated by the Hospital General Universitario de Alicante. Dr. Artemio Paya
  • Project 4.- "Molecular disturbance identification with sporadic and familial colon cancer (genome-wide scan). Case-control study". Coordinated by the Fundación Pública Gallega de Medicina Genómica. Dr. Clara Ruiz and Dr. Ángel Carracedo

Contact

Coordinator:
Montserrat Andreu

Tel:
93 248 32 19

Fax:
93 248 33 76

Pg Marítim, 25-29
08003 Barcelona

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