News
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26/04/2016 - Press release
A new genetic test improves and expands the detection of mutations that cause resistance to colon cancer treatments
The expansion of the genetic test allows the detection of newly identified mutations by a team of oncologists at Hospital del Mar and the IMIM that explain a further 10-15% of the resistance to a group of drugs developed by colorectal tumours The resistance caused by EGFR mutations described by the same team of oncologist has been shown to be important in more of 25% of the patients treated using anti-EGFR therapy This work is a clear example of how in just a short time the results of a research project have been transferred to industry, in this case the Belgian multinational Biocartis, and how they have an almost immediate application in patients, improving and personalising colon cancer treatments The patent for the first test was obtained in 2013, the detection kit was marketed in 2014, and it has now been expanded, with a new licence, to include the newly-detected mutations
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08/02/2016 - Institutional news
AECC funds IMIM and Hospital del Mar project on possible new biomarker for prostate and bladder cancer
On February 4, to coincide with World Cancer Day, the AECC-Catalunya contra el Càncer, presented their Cancer Research Grants 2015 at the Drassanes Reials in Barcelona, in a ceremony attended by more than 400 people from the worlds of politics and business, as well as the general public. In this edition the AECC presented a total of €120,000 to six projects by emerging Catalan teams looking at colon cancer, leukaemia, brain tumours, gastrointestinal stromal tumours and prostate and bladder cancer. The winners include a project entitled: “Clinical implications of galectin-1 expression in genitourinary cancer: its role in diagnosis, prognosis and response prediction with immune check point inhibitors”, led by Pilar Navarro, coordinator of the Molecular Mechanisms of Tumorigenesis research group at the IMIM and Alejo Rodríguez-Vida, an oncologist at the Hospital del Mar
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23/10/2014 - Press release
A new therapeutic target identified for the most widespread cutaneous lymphoma
Researchers at the Hospital del Mar have discovered one of the key mechanisms in the development and progression of mycosis fungoide, a type of cancer originating in the lymphoid cells that develops initially on the skin. The study, published in the Journal of Investigative Dermatology, was co-led by Fernando Gallardo, a dermatologist at the Hospital del Mar and a researcher in the translational research group on haematopoietic malignancies at the Hospital del Mar Medical Research Institute (IMIM); Luis Espinosa and Anna Bigas from the IMIM Cancer Stem Cells Laboratory; Juan Sandoval, researcher at the La Fe Research Institute (IISlaFe); and Ángel Diaz, researcher at the Bellvitge Biomedical Research Institute (IDIBELL). The project was conducted with a series of skin samples from patients with mycosis fungoide in tumour phase and led to the identification of the miR-200C molecule as a possible therapeutic target for designing future treatments for this disease.
Més informació "A new therapeutic target identified for the most widespread cutaneous lymphoma"
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14/10/2015 - Press release
A step forward in obtaining blood stem cells in laboratory
An international study led by researchers from IMIM (Hospital del Mar Medical Research Institute) published in the journal Nature Communications has revealed that the intensity or efficiency of the activation of a protein called Notch, which is involved in the different phases of embryonic development, determines the fate of cells, i.e. if cells will form the aorta artery or blood (hematopoietic) stem cells. For artery cells, many Notch molecules need to be activated, whereas for hematopoietic cells many fewer are needed. According to Dr. Anna Bigas, the coordinator of the group on stem cells and cancer at IMIM “to reach these levels of activation, we have proven that there is a competition between two proteins that activate the Notch molecule, i.e. between two ligands, in a way that one limits the activation generated by the other to form hematopoietic stem cells”. Until now it was known, thanks to the studies conducted by this same group and others, that the Notch activation was essential to form arteries and hematopoietic stem cells. It was also known that the proteins responsible for this activation were ligands Delta4 and Jagged1, respectively. With this study, researchers have shown how this signal works to reach a certain level of activation and form the two different types of cells.
Més informació "A step forward in obtaining blood stem cells in laboratory"
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04/10/2012 - Press release
New function of a protein involved in colon cancer is identified
Researchers from IMIM, have succeeded in determining the function of a new variant of enzyme IKKalpha (IKKα) to activate some of the genes taking part in the tumor progressions of colorectal cancer. In the future, this fact will make it possible to design new drugs that inhibit this enzyme specifically and are less toxic for the remaining body cells, hence improving the treatment for this disease.
Més informació "New function of a protein involved in colon cancer is identified"
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25/07/2012 - Press release
Key function of protein discovered for obtaining blood stem cells as source for transplants
Researchers from IMIM have deciphered the function executed by a protein called ?-catenin in generating blood tissue stem cells. These cells, also called haematopoietic, are used as a source for transplants that form part of the therapies to fight different types of leukaemia. The results obtained will open the doors to produce these stem cells in the laboratory and, thus, improve the quality and quantity of these surgical procedures. This will let patients with no compatible donors be able to benefit from this discovery in the future.
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19/06/2012 - Press release
A new indicator for breast cancer relapse identified
Researchers at the IMIM (Institut de Recerca Hospital del Mar) have proven that the absence of the 14-3-3 protein sigma in breast cancer cells is directly associated with these cells’ capacity to activate the signalling of a protein complex called NF-kB, which is related to tumour progression. The activation of NF-kB in tumours was also identified as the best indicator for relapse in breast cancer patients, compared to other parameters currently used, such as the presence of affected ganglions or the tumour’s size and degree.
Més informació "A new indicator for breast cancer relapse identified"
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12/04/2012 - Press release
New advances in the understanding of cancer progression
Researchers at the Hospital de Mar Research Institute (IMIM) have discovered that the protein LOXL2 has a function within the cell nucleus thus far unknown. They have also described a new chemical reaction of this protein on histone H3 that would be involved in gene silencing, one of which would be involved in the progression of breast, larynx, lung and skin tumours.
Més informació "New advances in the understanding of cancer progression"
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23/01/2012 - Press release
Identified a cause of resistance to colon cancer treatment
Doctors and researchers of Hospital del Mar and IMIM point to an acquired mutation during treatment as the causative mechanism of therapeutic failure. This discovery leads to new perspectives to improve the efficiency of treatments, the survival of patients and to advance in customized treatments against cancer
Més informació "Identified a cause of resistance to colon cancer treatment"
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04/12/2011 - Press release
Discovery of a new reprogramming mechanism for tumor cells
Nature Medicine publishes a pioneering study about a protein that regulates the expression of hundreds of genes that have a crucial role in the progression of pancreatic cancer, gliomas and possibly many other kinds of tumor. The study is directed by Pilar Navarro at the IMIM (Institut de Recerca Hospital del Mar, Barcelona) and Raúl Méndez, ICREA Research Professor at the Institute for Research in Biomedicine (IRB Barcelona).
Més informació "Discovery of a new reprogramming mechanism for tumor cells"
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