Hospital del Mar Research Institute Hospital del Mar Research Institute



Neuromodulation of cortical output circuits

Sala Charles Darwin (PRBB) a les 12:00 hores

En el marc de les sessions del Programa de Neurociències, el proper 22 de setembre a les 12:00 hores tindrà lloc a la Sala Charles Darwin (Plaça interior del PRBB) la sessió que porta per títol "Neuromodulation of cortical output circuits" impartida pel Dr. Allan Gulledge, professor associat de Dartmouth Geisel School of Medicine de New Hampshire, USA.

Resum (en anglès):

Pyramidal neurons in the mouse medial prefrontal cortex comprise two broad subclasses of neurons defined by their long-distance axonal projections: intratelencephalic neurons, which include commissural/callosal (COM) projection neurons, and corticofugal neurons, which include those projecting to the pons (CPn neurons). COM and CPn neurons are differentially regulated by modulatory neurotransmitters, including serotonin (5-HT) and acetylcholine (ACh). While CPn neurons are universally inhibited via Gi/o-coupled 5-HT1A (1A) receptors, COM neurons are excited via Gq- coupled 5-HT2A (2A) receptors. Further, although both neuron subpopulations express Gq-coupled M1 muscarinic ACh receptors, ACh preferentially enhances the excitability of CPn neurons. This suggests that 5-HT and ACh may exert opposing influences on corticofugal output to the brainstem. Consistent with this hypothesis, we find that release of endogenous ACh selectively and persistently increase action potential output in CPn neurons (for up to 60 s) through at least three distinct mechanisms, including suppression of M- current and activation of a calcium-permeable conductance. Our findings demonstrate that 5-HT and ACh exert reciprocal control over corticofugal output to the brainstem.

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