Agenda

18/04/2017

Can genetics identify true causal associations between exposure and outcome? The Mendelian randomization approach

Sala Xipre (173.06-1a planta IMIM) a les 13:00 hores

El proper dimarts 18 d'abril tindrà lloc la sessió "Can genetics identify true causal associations between exposure and outcome? The Mendelian randomization approach" organitzada pel Grup de Recerca en Epidemiologia i Genètica Cardiovasculars de l'IMIM. La sessió anirà a càrrec de Robert Carreras, investigador postdoctoral del Grup d'Epidemiologia Genètica (GEP) al IARC (International Agency for Research on Cancer (IARC/WHO), Lyon.

Resum

The role of bias and confounding can not be easily excluded from observational epidemiology results. Mendelian randomization (MR) is an analytical approach based on genetic markers to test causality between phenotypes and to provide unconfounded association estimates. Genetic variants associated with exposure parameters should act as unconfounded instruments to test the relationship between exposures and outcome. These genetic variants are randomly allocated at conception on the tested sample, are not going to be affected by reverse causation, and have less chance to be associated with potential confounders.

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