IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

Immunity and Infection Miguel López-Botet

The group gathers personnel from IMIM and University Pompeu Fabra (UPF) and is coordinated by Miguel López-Botet (ORCID, CV sketch), who has a double appointment with both institutions (Professor and Head of the Immunology Service at Hospital del Mar). Laboratories are located at the Barcelona Biomedical Research Park (PRBB) premises.

The team has a long-standing experience on the study of human Natural Killer (NK) cell biology, involved in the immune response against infections and tumors. Our most relevant past contributions were the characterization of CD94/NKG2 and ILT2 (LIR1, CD85j, LILRB1) receptors specific for HLA class I molecules. The role of NK cells in the response to human cytomegalovirus (HCMV) is currently being assessed. This highly prevalent and persistent herpes virus infection may cause severe congenital neurological disorders in newborns, and constitutes a common threat for immunocompromised patients.

We originally reported that HCMV may promote a marked reconfiguration of the NK cell compartment in some individuals. Our attention is mainly focused to:

a) unravel the mechanism(s) of this pattern of adaptive NK cell response to the viral infection;

b) explore its implications in the immune response to other pathogens and tumors, as well as in the pathophysiology of chronic inflammatory disorders.

These issues are being addressed both at the experimental level and through collaborations with clinical teams at Hospital del Mar, mainly including the Departments of Nephrology, Oncology and Neurology. At present, a special effort is being devoted for translating our expertise into the field of cancer immunology (coordinated by Dr. A. Muntasell).

Contact

Coordinator:
Miguel López-Botet

Tel:
93 316 03 86

Fax:
93 316 04 10

Dr. Aiguader, 88
08003 Barcelona

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