IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

News

  • 26/05/2016 - Events

    Biomarker discovered that measures the risk of cancer in non-smokers

    Researchers from the Hospital del Mar Medical Research Institute (IMIM) have, for the first time, demonstrated that measurements of a tobacco-specific nitrosamine in the hair, NNK, correlate with the real risk of exposure to the carcinogens in tobacco smoke in passive smokers. This substance is a much better biomarker than any of the markers measured up to now for assessing this risk and it has been found in higher concentrations in the hair than any other tobacco-specific carcinogen. The study was conducted in collaboration with researchers at the Catalan Institute of Oncology (ICO) and has been published in the journal Scientific Reports. The smoke passive smokers are exposed to differs from the smoke of smokers. Passive smokers are exposed to a lot of chemicals resulting from the combustion of the cigarette, but in addition, certain substances have gone through various activation reactions, making them carcinogenic.

    Més informació "Biomarker discovered that measures the risk of cancer in non-smokers"

  • 26/05/2016 - Press release

    European project eTOX launches a new video

    When bringing to market any new drug efficiency and safety are essential. R+D Departments in pharmaceutical companies spend lots of efforts to make sure the new compounds meet the highest standards. In the process, large amounts of useful information are produced, that traditionally end up buried in the archives of pharmaceutical companies. Committed to avoiding duplicating processes, wasting time and resources, 13 pharmaceutical industries, 7 academic institutions and 5 SMEs launched the eTOX project. The result of the project will be a comprehensive database with toxicity studies for thousands of drugs (or drug candidates) and a collection of original software applications for toxicity prediction. 

    Més informació "European project eTOX launches a new video"

  • 25/05/2016 - Events

    New evidence on molecular mechanisms involved in psoriasis outset

    Two translational research studies by the University of Barcelona have described new immunologic mechanisms in psoriasis, a chronic cutaneous inflammatory disease which affects around the 2% of the population. The studies, published in the high impact scientific magazines Journal of Allergy and Clinical Immunology and Journal of Investigative Dermatology , have analysed the molecular processes involved in the IL-17 cytokine –a protein family of the immune system- with samples of patients with psoriasis. These results are important to understand the origins of psoriasis and develop more specific pharmaceutical treatments, since the IL-17 blocking is a new therapeutic strategy which is very effective when controlling this illness. The studies have been led by Lluís Francesc Santamaria, Director of the group of Translationary Immunology of the University of Barcelona based at the Barcelona Science Park, together with researchers of the Hospital del Mar and the Municipal Institute for Medical Research, among others.

    Més informació "New evidence on molecular mechanisms involved in psoriasis outset"

  • 26/04/2016 - Press release

    A new genetic test improves and expands the detection of mutations that cause resistance to colon cancer treatments

    The expansion of the genetic test allows the detection of newly identified mutations by a team of oncologists at Hospital del Mar and the IMIM that explain a further 10-15% of the resistance to a group of drugs developed by colorectal tumours The resistance caused by EGFR mutations described by the same team of oncologist has been shown to be important in more of 25% of the patients treated using anti-EGFR therapy This work is a clear example of how in just a short time the results of a research project have been transferred to industry, in this case the Belgian multinational Biocartis, and how they have an almost immediate application in patients, improving and personalising colon cancer treatments The patent for the first test was obtained in 2013, the detection kit was marketed in 2014, and it has now been expanded, with a new licence, to include the newly-detected mutations

    Més informació "A new genetic test improves and expands the detection of mutations that cause resistance to colon cancer treatments"

  • 31/03/2016 - Press release

    Hospital del Mar and Vall d'Hebron take part in the biggest international genomic study into strokes

    The Hospital del Mar Medical Research Institute and the Vall d'Hebron Research Institute, in collaboration with the MútuaTerrassa Foundation, were the only Spanish research centres to participate in the largest study to date into genome association with ischaemic stroke, and which involved around 38,000 patients and 400,000 control subjects. The study, published recently in Lancet Neurology by two international consortia, has led to the identification of a gene implicated in atherothrombotic ischaemic stroke. The team of Dr. Jordi Jiménez-Conde, head of the Genetics Area within the Neurovascular Research Group at the IMIM and a neurologist at the Hospital del Mar, took part in the discovery phase of the study. This first part involved the analysis of nearly 900 samples from stroke patients and 1200 controls from the Hospital del Mar, this being the second-ranked centre internationally according number of cases.

    Més informació "Hospital del Mar and Vall d'Hebron take part in the biggest international genomic study into strokes"

  • 1/03/2016 - Press release

    Regulating neuronal membrane lipids could be the key to Alzheimer's and Parkinson's

    A study published in the prestigious journal Scientific Reports from the Nature group demonstrates, for the first time and using computational tools, that polyunsaturated lipids can alter the binding rate of two types of receivers involved in certain nervous system diseases. The work was led by members of the Research Programme on Biomedical Informatics at the IMIM (Hospital del Mar Medical Research Institute) and Pompeu Fabra University as well as researchers from the University of Tampere (Finland), and also involved scientists from the University of Barcelona. Using latest-generation molecular simulations, which are like “computational microscopes”, the researchers have demonstrated that a decrease in polyunsaturated lipids in neuronal membranes, as seen in Parkinson's and Alzheimer's sufferers, directly affects the binding rate of dopamine and adenosine receptors. 

    Més informació "Regulating neuronal membrane lipids could be the key to Alzheimer's and Parkinson's"

  • 11/02/2016 - Press release

    People with mental disorders have an increased risk of developing chronic physical diseases

    People with anxiety disorders have an increased risk of suffering chronic diseases such as heart disease, chronic pain, and peptic ulcers. This is one of the conclusions of a new study published in JAMA Psychiatry, led by the University of Otago (New Zealand) and involving Dr Jordi Alonso, director of the Epidemiology and Public Health programme at the Hospital del Mar Medical Research Institute (IMIM) and a CIBERESP researcher. The study found that all kinds of mental health disorders, related to mood, anxiety, and impulse control, as well as substance use disorders, are associated with an increased risk of a wide range of chronic physical diseases. The researchers studied the relationship between mental disorders and ten diseases: arthritis, chronic pain, heart disease, stroke, hypertension, diabetes, asthma, chronic lung disease, peptic ulcers, and cancer.

    Més informació "People with mental disorders have an increased risk of developing chronic physical diseases"

  • 08/02/2016 - Press release

    New type 2 diabetes biomarker identified

    Researchers from the Hospital del Mar Medical Research Institute (IMIM) have found an epigenetic mechanism implicated in the regulation of blood sugar. The study, published in the journal Molecular Human Genetics, reveals that the methylation of the TXNIP gene is associated with diabetes mellitus type 2 and, in particular, average blood glucose levels. These results, replicated in two patient cohorts, could help to both identify patients at risk of developing diabetes and control treatment response, as well as generating possible future therapies for this disease, one of the major cardiovascular risk factors in the population. The work was coordinated by Carolina Soriano, from the Neurovascular research group at the IMIM, and Jordi Jiménez Conde, from the same group and a neurologist at the Hospital del Mar, in collaboration with the IMIM's Cardiovascular Epidemiology and Genetics group. 

    Més informació "New type 2 diabetes biomarker identified"

  • 08/02/2016 - Institutional news

    AECC funds IMIM and Hospital del Mar project on possible new biomarker for prostate and bladder cancer

    On February 4, to coincide with World Cancer Day, the AECC-Catalunya contra el Càncer, presented their Cancer Research Grants 2015 at the Drassanes Reials in Barcelona, in a ceremony attended by more than 400 people from the worlds of politics and business, as well as the general public. In this edition the AECC presented a total of €120,000 to six projects by emerging Catalan teams looking at colon cancer, leukaemia, brain tumours, gastrointestinal stromal tumours and prostate and bladder cancer. The winners include a project entitled: “Clinical implications of galectin-1 expression in genitourinary cancer: its role in diagnosis, prognosis and response prediction with immune check point inhibitors”, led by Pilar Navarro, coordinator of the Molecular Mechanisms of Tumorigenesis research group at the IMIM and Alejo Rodríguez-Vida, an oncologist at the Hospital del Mar

    Més informació "AECC funds IMIM and Hospital del Mar project on possible new biomarker for prostate and bladder cancer"

  • 27/01/2016 - Press release

    Spending more on food is associated with a healthier diet and weight

    According to an epidemiological study carried out by researchers at the Hospital del Mar Medical Research Institute (IMIM), increasing the money you spend on food is linked to a better quality diet, particularly increased consumption of fruit and vegetables, leading to a healthier weight and decreased risk of cardiometabolic diseases like obesity, diabetes, and cardiovascular problems. The researchers monitored a group of 2181 Spanish men and women aged 25 to 74, all part of the REGICOR (Registre Gironí del Cor) programme, for a period of ten years. They measured their height and weight, and recorded dietary data obtained from a scientifically validated food frequency questionnaire. The average food cost was calculated using official government data.

    Més informació "Spending more on food is associated with a healthier diet and weight"

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