IMIM - Institut Hospital del Mar d'Investigacions Mèdiques IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

Agenda

10/03/2022

Regulatory RNAs: interactions drive functionalities

Hibrid (Sala xipre i virtual) a les 11:30h

Us convidem al pròxim IMIM Invited speakers Seminar, que tindrà lloc el dijous 10/03/2022 a les 11:30 h en format hibrid. El títol serà "Regulatory RNAs: interactions drive functionalities", a càrrec del Dr. Manolo Beltran del Dept. Biology and Biotechnology "C. Darwin". Sapienza, University of Rome.

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We invite you to the next IMIM Invited speakers Seminar, which will take place on Thursday 10/03/2022 at 11:30 h in hybrid format. The title will be "Regulatory RNAs: interactions drive functionalities",by Dr. Manolo Beltran from the Dept. Biology and Biotechnology "C. Darwin". Sapienza, University of Rome.

Abstract:

Many processes of gene expression control rely on RNA-based regulatory circuitries. To carry out these activities, RNA not only interacts with proteins and chromatin but often directly pairs with other RNA molecules. During my I will present examples underlining the importance of RNA as a core component of gene regulation. First demonstrating the role of nascent RNA regulating the accession to the chromatin of several nucleosome modifiers factors, such as Polycomb Repressive Complex 2 (PRC2). Or by focusing on how RNA-RNA interactions also play an important role in gene regulation. Specifically, showing how the interaction between CKAP5 mRNA and circZNF609 regulates microtubule function in cancer cells. Finally, I will show that targeting those RNA-RNA or RNA-protein interactions increases the sensitivity of several cancer cell lines to different microtubule-affecting chemotherapeutic drugs. These data set an example of how the little effects tuned by RNA as a signaling molecule might have a potent output in tumour growth and drug response.

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