IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

Agenda

04/11/2015

"New generation biomarkers based on mechanistic insight into disease" a càrrec del Dr. Joaquín Dopazo

Sala Ramón y Cajal (Plaça interior PRBB) a les 12 hores

En el marc del Programa de recerca en informàtica biomèdica, el proper dia 4 de novembre a les 12:00h tindrà lloc a la Sala Ramón y Cajal la sessió "New generation biomarkers based on mechanistic insight into disease" a càrrec del Dr. Joaquín Dopazo, cap del Departament de Genòmica Computacional del Centro de Investigación Príncipe Felipe (CIPF) de Valencia.

Resum en anglès

The impact of the genomic revolution in the field of medicine has been enormous. The concept of personalized medicine has evolved to precision medicine, which aims to find better ways of defining diseases by relating conventional clinical-pathological diagnostic criteria with state-of-the-art molecular profiling methodologies. Besides, a more precise diagnostic of the disease, based on the description of their molecular mechanisms would allow creating innovative diagnostic, prognostic, and therapeutic strategies precisely tailored to each patient's requirements. To achieve this, a deeper, systems-based understanding of these disease drivers is required. Here I will discuss how primary gene expression and gene variation data can be integrated and transformed into mechanism-based biomarkers containing higher-level information on disease mechanisms by means of relatively simple models of functional pathways.

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